alpha:[0* TO 9*] - Manufacturers, Suppliers & Exporters
Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:53:10 ]
APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2; a unique small molecular IL-12/23 production inhibitor.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:50:07 ]
Terbutaline sulfate is a β2-adrenergic receptor agonist; a fast-acting bronchodilator and a tocolytic to delay premature labor.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:46:28 ]
Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt) , EGFR(L858R) , EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:42:45 ]
Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:39:48 ]
1,4-Dioxaspiro[4.5]decan-8-one Name 1,4-Dioxaspiro[4.5]decan-8-one Synonym 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL;1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL;1,4-DIOXASPIRO[4.5]DECAN-8-ONE;1,4-DIOXASPIRO[4.5]-8-DECANONE;CYCLOHEXANEDIONE(1,4-) MONOETHYLENE;Cyclohexane-1,4-dione mono
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:38:13 ]
ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE Name ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE Synonym RARECHEM AL BI 0472;ETHYL BENZOTHIAZOLE-2-CARBOXYLATE;ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE;2-Benzothiazolecarboxylicacid,ethylester(6CI,9CI);Benzothiazole-2-carboxylic acid ethyl ester;2-Ben
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:35:50 ]
Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:35:50 ]
L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:29:47 ]
Name (S)-2-AMINOBUTYRAMIDE HYDROCHLORIDE Synonym (S)-2-AMINOBUTYRAMIDE HYDROCHLORIDE (S)-2-AMINOBUTANAMIDE HYDROCHLORIDE (S)-2-AMINOBUTYRAMIDE HCL ABAH LEVETIRACETAM'S INTERMEDIATE (2S)-2-AMINOBUTANAMIDE HYDROCHLORIDE (1 1) 2-AMINOBUTANAMIDE HYDROCHLORIDE (1 1) (L)-2-AMINOBUTYRAM
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:26:17 ]
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Name (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Synonym (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate;(R)-[3-(3-Fluoro-4-Mo
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:24:27 ]
AM095 is an LPA1 receptor antagonist with good oral exposure and antifibrotic activity in rodent models. In vitro, AM095 inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, re
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:23:56 ]
AP-26113 exhibited approx 100-fold selectivity for ALK-positive lines compared with a approx 10-fold selectivity for PF-1066. At the highest doses tested, strong regressions were achieved with AP-26113, but not PF-1066 .AP-26113 inhibited the tumor growth at 25 mg/kg in ALCL and
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:19:12 ]
Asenapine maleate(Org 5222 maleate) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:14:21 ]
AT13387 is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:10:11 ]
AT9283 is a small molecule a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), JAK2 and JAK3, Aurora A and Aurora B, respectively.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:06:37 ]
AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM; >1400-fold selectivity over the other kinases assayed.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:01:57 ]
Axitinib is a multi-target inhibitor of VEGFR1 , VEGFR2 , VEGFR3 , PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 09:57:37 ]
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein p
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 09:51:30 ]
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 09:46:36 ]
