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Combined with the receptors of the anterior pituitary cells, the short-term increase in plasma sex hormone levels. Further use of therapeutic doses resulted in (on average, 12-14
days) complete blockade of pituitary gonadotropic function, thereby inhibiting the release of LH and FSH. As a result, the synthesis of sex hormones in the ovaries was inhibited and the concentration
of estradiol (E-2) in the plasma decreased to postmenopausal levels.