Human KCNC1 Stable Cell Line-CHO

Kv3.1 mRNA is abundantly expressed in auditory brain stem neurons that are able to spike at high frequencies. It has a high threshold of activation and rapid activation/deactivation kinetics. Evidence for functional Kv3.1 activity in such neurons can be derived from the rapidly ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:54:21 ]

Human KCNC2 Stable Cell Line-CHO

Kv3.2 channels are expressed in neurons known to fire at high frequency. Their biophysical properties could enable cells to generate the fast chains of action potentials involved in neuronal excitability. They are thought to play a role in the regulation of the human 24hr ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:53:51 ]

Human KCNC3 Stable Cell Line-CHO

Kv3.3 are voltage-gated, fast inactivating Shaw channels which play an important role in regulating neuronal output by modulating the delay and frequency of high frequency neuronal firing. They are highly expressed in areas of the brain involved with motor control such as the ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:53:20 ]

Human KCND3/KCNIP1 Stable Cell Line-CHO

Rapidlly inactivating voltage sensitive potassium channels are found both in neurons (A-current) and cardiac myocytes (Ito) where they are responsible of the \"notch’ in phase 1 of the cardiac action potential. The channels underlying Ito in humans are principally Kv4.3 and ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:52:37 ]

Human KCNQ4 Stable Cell Line-HEK293

KCNQ genes encode potassium channels that have been associated with both cardiac and hearing abnormalities in humans, most notably the KNCQ1 gene. Using a partial KCNQ3 cDNA Kubisch et al. screened a human retinal cDNA lambda phage library and obtained a novel homolog they ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:52:07 ]

Human KCNQ4/KCNQ5 Stable Cell Line-HEK293

Potassium ion channels are the most widely distributed of ion channels and are found in almost all living organisms. A typical voltage gated potassium ion channel has a tetrameric structure consisting of 4 protein subunits combining to form a central ion conducting pore across ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:51:38 ]

Human SCN1A Stable Cell Line-HEK293

The voltage gated sodium channel isoform Nav1.1 is involved with axon potential initiation and repetitive neuronal firing as well as the contraction-excitation coupling of cardiac myocytes. Nav1.1 is the target of antiepileptic drugs and the probable target causing side effects ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:51:08 ]

Human KCND3/KCNIP2 Stable Cell Line-HEK293

Kv4 subunits are the main pore-forming proteins responsible for the fast transient outward currents observed in the CNS (rat brain), where they have been described as \"A’ currents (IA) and in mammalian heart, where they are known as Ca2+-independent fast outward currents ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:50:36 ]

Human KCNQ2/KCNQ3 Stable Cell Line-CHO

Kv7.2 and Kv7.3 are both voltage-gated, delayed rectifier potassium channels. Together they co assemble to form the M current in the brain. The M current is a slowly activating and deactivating potassium conductance that plays a crucial role in determining the excitability of ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:50:05 ]

Human KCNQ3/KCNQ5 Stable Cell Line-CHO

In Mammals, one of the most physiologically-relevant and studied currents is the M current, named this because it is a current observed in neurons in response to addition of muscarine. The M current is inhibited by various brain peptides and M1 muscarinic acetycholine GPCRS. M ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:49:36 ]

Human SCN2A Stable Cell Line-CHO

The voltage gated sodium channel isoform Nav1.2 is involved with axon potential initiation and conduction. Nav1.2 is the target of antiepileptic drugs and the probable target causing side effects of centrally active local anaesthetics. It is detected in relative abundance on ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:48:42 ]

Human SCN5A Stable Cell Line-HEK293

Nav1.5 is expressed in cardiac myocytes and involved with action potential initiation and conduction. Mutations of Nav1.5 result in QT prolongation and ventricular fibrillation. This ion channel is a target for anti-arrhythmic drugs and the toxic side effects of local ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:48:10 ]

Rat Nav1.8 Stable Cell Line-ND7-23

Nav1.8 subtype selective blockers are predicted to be effective in the treatment of neuropathic pain and to be associated with fewer adverse effects than currently available therapies. Drugs for the clinical treatment of neuropathic pain can interact with other members of the ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:47:36 ]

Human TRPA1 Stable Cell Line-HEK293

Human TRPA1 Stable Cell Line-HEK293 There is now compelling evidence to suggest that TRPA1 is primarily responsible for mediating sensations of noxious cold https://www.creative-biogene.com/Human-TRPA1-Stable-Cell-Line-HEK293-196362-12.html ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:47:00 ]

Human TRPV1 Stable Cell Line-HEK293

The TRPV1 (Transient Receptor Potential Vanilloid subtype 1) channels cation channels mediate neuronal responses to many noxious stimuli, including heat, low pH, neuropeptides and chemicals e.g. the capsaisin molecule responsible for the sensation of heat from chillies. This ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:46:02 ]

Human TRPV3 Stable Cell Line-HEK293

The TRPV3 channel belongs to the transient receptor potential channel (TRP) super-family that consists of 7 subfamilies. The channels exist as tetramers where each subunit consists of 6 putative trans-membrane domains. In this respect they have a similar topology to many other ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:45:31 ]

Human HTR3A Stable Cell Line-HEK293

The human HTR3A gene encodes the pore-forming subunit of 5-HT3A, a ligand-gated cation channel activated by 5-hydroxytryptamine (serotonin). 5-HT3A channels expressed in the CNS and GI tract, are therapeutic targets in nausea and irritable bowel syndrome. ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:44:58 ]

Human CHRNA3/CHRNB4 Stable Cell Line-CHO

Nicotinic receptors (nAChR) are acetylcholine-activated non-selective cation channels that mediate excitatory neurotransmission. The receptor-channels are configured as hetero- or homopentamers. The human CHRNA3 and CHRNB4 genes encode a cationic-selective, ionotropic ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:44:21 ]

Human ACCN2 Stable Cell Line-CHO

The human ACCN2 gene encodes the pore-forming subunit of ASIC1a, a proton-activated, channel permeable to both Na+ and Ca2+ ions. ASIC1a channels widely expressed in the neurons of peripheral sensory and the central nervous system are therapeutic targets in pain and ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:43:51 ]

Human ACCN1 Stable Cell Line-CHO

The human ACCN1 gene encodes the pore-forming subunit of ASIC2a, a proton-activated, Na+-permeable channel. ASIC2a channels widely expressed in sensory neurons of the peripheral and central nervous systems are therapeutic targets in pain and neurodegenerative diseases. ...

Creative Biogene    [Health & Medical]   [Drugs]   [2017-11-24 03:42:10 ]