Obeticholic Acid

Place Of Origin
China
Minimum Order
11
Packaging
vial
Delivery
15 Days
Product Name: Obeticholic Acid
Synonyms: 6-Ethylchenodeoxycholic acid;6alpha-Ethyl-chenodeoxycholic acid;6-Ecdca;6-Ethyl-cdca;C15636;6-Ethylchenodeoxycholic acid(Obeticholic Acid);Obeticholic Acid;(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid
CAS: 459789-99-2
MF: C26H44O4
MW: 420.63
density 1.091
Appearance : White powders
Purity : 99%
Package : 1kg/foil bag
Related categories: pharmaceutical intermediates; pharmaceutical raw materials; Aobei acid; API
Usage : Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM.

In vitro:

In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM.

In vivo:

In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. Obeticholic Acid (p.o.) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension.

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