(R)-(+)-9-(2-Hydroxypropyl)adenine

(R)-(+)-9-(2-Hydroxypropyl)adenine

Name:(R)-(+)-9-(2-Hydroxypropyl)adenine

Synonym:R-9-(2-hydroxypropyl) adenine, 9-HPA;(R)-(+)-9-(2-HYDROXYPROPYL)ADENINE,98%;(R)-(+)-9-(2-Hydroxypropyl)adenine;6-Amino-alpha-methyl-9H-purine-9-ethanol;D-(-)-9-(2-Hydroxypropyl)adenine;(R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir);(R)-6-aMino-alpha-Methyl-9H-purine-9-ethanol;(R)-9-(2-Hydroxypropyl)ademine

CAS: 14047-28-0

Assay: 99%

M.F: C8H11N5O

M.W: 193.21

MP: 193°C

BP: 457.7°C at 760 mmHg

Density: 1.57

Appearance: white powder

Application: Tenofovir intermediate

Package: 25kg/drum

Standard: enterprise standard

Abiut Tenofovir: Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug.

About our company:

Wuhan YC Technology Co., Ltd. is a high-tech enterprises in Hubei Province, which is professional engaged in fine chemicals, flavors and fragrances, food additives, pharmaceutical raw materials and intermediates products research, development, production, management, sales in one of the high-tech chemical enterprise. Our company has its own import and export rights, the products sell well all over the country and exported to Europe and the United States and Southeast Asia, more than and 20 countries and area, praised by customers

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