CZC24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay); exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:27:07 ]
RKI-1447 inhibits potently ROCK1 and ROCK2 in a dose-dependent manner with IC50 values of 14.5 nM and 6.2 nM, respectively. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but had no effect on the phosphorylation levels of the AK
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:23:13 ]
SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:18:17 ]
UNC2250 is a phosphorylation of endogenous Mer inhibitor with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:15:28 ]
AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:11:21 ]
PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:08:40 ]
Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:05:15 ]
ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:02:10 ]
NVP-BGJ398(BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:59:04 ]
Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:52:54 ]
GSK 525762A is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4, binds to the tandem bromodomains of BET with Kd of 50.5-61.3 nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5 nM in
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:48:50 ]
Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Name Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Molecular Formula C11H9N3O5 CAS 82551-63-1 Synonyms p-Nitrobenzyl a-diazoacetoacetate; p-Nitrobenzyl 2-diazoacetoacetate; InChI InChI=1/C11H9N3O5/c1-7(15)10(1
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:57:43 ]
5-hydroxy-4-methoxy-2-nitro-benzaldehyde Name 5-hydroxy-4-methoxy-2-nitro-benzaldehyde CAS 58749-47-6 Package 25kg/drum Standard enterprise Standard MOQ 1kg Price 500 us$/kg
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:51:14 ]
Brexpiprazole (OPC-34712) is a close structural analog of aripiprazole and shares some of its pharmacological properties. Similarly to aripiprazole, brexpiprazole exhibits partial agonism of D2R and an enhanced affinity for specific serotonin receptors (e g., 5-HT1A, 5-HT2A and 5
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:43:47 ]
Ispinesib is a potent, allosteric, reversible, and specific inhibitor of KSP, which changes the binding property of KSP to microtubules and disturbs its movement by inhibiting ADP release without altering the release of the KSP-ADP complex from the microtubule. Ispinesib shows po
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:40:58 ]
N-(2-Chlorobenzyloxycarbonyloxy)succinimide CAS 65853-65-8 MF C12H10ClNO5 MW 283.66 mp 102-105 °C(lit.) storage temp. Store at RT. Chemical Properties Very faintly beige powder Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$150
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:38:32 ]
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:34:13 ]
MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM).
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:30:36 ]
2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride CAS 908591-25-3 MF C8H14N2S HCl MW 206.74 mp 62-65°C storage temp. Hygroscopic, Refrigerator, Under Inert Atmosphere Chemical Properties White to slightly yellow crystalline powder Usage Intermediate for Ritonavir, a ki
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:25:51 ]
AEE788(NVP-AEE 788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:24:23 ]
