BS-181 is a small molecule inhibitor of CDK7 in a cell-free environment, which displays more potential activity than roscovitine with IC 50 of 510 nM. Among the CDKs and other 69 kinases from many different classes, BS-181 shows high inhibitory selectivity for CDK7, inhibits CDK2
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:05:01 ]
5-chloro-2,3-difluoropyridine Name 5-chloro-2,3-difluoropyridine EINECS 410-090-7 Molecular Formula C5H2ClF2N CAS 89402-43-7 Synonyms 2,3-DIFLUORO-5-CHLOROPYRIDIN; 2,3-DIFLUORO-5-CHLOROPYRIDINE; 5-Chloro-2,3-Difluoropyridine96%; 2,3-Difluoro-5-Chloro; 2,3-Difulor-5-Chloropyridin
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:02:51 ]
PLX647 was tested against a panel of 400 kinases at a concentration of 1 μM, 35-fold above its FMS enzymatic IC50 and 60-fold above its KIT enzymatic IC50. In addition to FMS and KIT, the activities of only nine kinases were inhibited by more than 50%. PLX647 potently inhibits t
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:01:11 ]
AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:58:04 ]
Indazole-3-carboxylic acid CAS 4498-67-3 MF C8H6N2O2 MW 162.15 EINECS 224-794-5 mp 266-270 °C (dec.) storage temp. Refrigerator Chemical Properties yellow crystal Usage Indole derivatives useful in treatment of pain and inflammation Purity 99% Usage API Package 1KG foil bag; 25K
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:53:16 ]
Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:53:10 ]
Tricyclo[3.3.1.13,7]decane-1-carboxylicacid Name Tricyclo[3.3.1.13,7]decane-1-carboxylicacid EINECS 212-584-6 Molecular Formula C11H16O2 CAS 828-51-3 Synonyms 1-Adamantanecarboxylicacid (6CI,7CI,8CI); 1-Adamantane-1-carboxylic acid; 1-Carboxyadamantane; Adamantoic acid; 1-Admant
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:51:17 ]
APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2; a unique small molecular IL-12/23 production inhibitor.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:50:07 ]
Terbutaline sulfate is a β2-adrenergic receptor agonist; a fast-acting bronchodilator and a tocolytic to delay premature labor.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:46:28 ]
Chlorophenylpiperazinehydrochloride Name Chlorophenylpiperazinehydrochloride Synonym 1-(3-Chlorophenyl)piperazine monohydrochloride; 1-(3-chlorophenyl)piperazine hydrochloride; Piperazine, 1-(3-chlorophenyl)-, monohydrochloride; 1-(3-chlorophenyl)piperazine monohcl; 1-(3-chloroph
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:43:20 ]
Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt) , EGFR(L858R) , EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:42:45 ]
Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:39:48 ]
ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE Name ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE Synonym RARECHEM AL BI 0472;ETHYL BENZOTHIAZOLE-2-CARBOXYLATE;ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE;2-Benzothiazolecarboxylicacid,ethylester(6CI,9CI);Benzothiazole-2-carboxylic acid ethyl ester;2-Ben
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:35:50 ]
Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:35:50 ]
1,3-DICYCLOHEXYL-IMIDAZOLIUM CHLORIDE CAS 181422-72-0 MF C15H25ClN2 MW 268.83 Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$33333
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:30:32 ]
L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:29:47 ]
1,1-Cyclobutanedicarboxylic acid CAS 5445-51-2 MF C6H8O4 MW 144.13 EINECS 226-651-2 mp 158 °C(lit.) Chemical Properties white fine crystalline powder Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$250
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:26:54 ]
(S)-(-)-Indoline-2-carboxylic acid Name (S)-(-)-Indoline-2-carboxylic acid Synonym (R)-1H-INDOLE-2-CARBOXYLIC ACID;(R)-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID;(R)-(+)-2,3-DIHYDROINDOLE-2-CARBOXYLIC ACID;Perindopril Intermediate;(2S)-indoline-2-carboxylic acid;(2S)-2,3-dihydro-1H-
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 10:25:11 ]
AM095 is an LPA1 receptor antagonist with good oral exposure and antifibrotic activity in rodent models. In vitro, AM095 inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, re
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:23:56 ]
AP-26113 exhibited approx 100-fold selectivity for ALK-positive lines compared with a approx 10-fold selectivity for PF-1066. At the highest doses tested, strong regressions were achieved with AP-26113, but not PF-1066 .AP-26113 inhibited the tumor growth at 25 mg/kg in ALCL and
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:19:12 ]
