hair removal - oral medications
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Promoted for use in treating pattern baldness in men, it is a type 2, 5-alpha-reductase inhibitor. This enzyme
Spironolactone is a diuretic, so it is advised to drink plenty of water during the therapy. The side effects with Spironolactone are generally transient. As with all anti-androgens, Spironolactone therapy should be avoided during pregnancy and in women who have a family history of breast cancer, although there is no proven association between Spironolactone and breast malignancy.
Treatment protocols may require continuous Spironolactone use at 50mg to 200mg per day or periodic use. Combining this treatment with an oral contraceptive pill or Dexamethasone appears to have an improved beneficial effect on hirsutism, and limits and removes some of the side effects.
Spironolactone (also known as Aldactone) is arguably the number 1 (hirsutism) treatment of choice for dermatologists. Spironolactone has several properties that make it effective in treating hirsutism. It interferes with and limits the production of androgens and it increases the metabolism of any testosterone that is produced. Spironolactone binds to the cell's androgen receptors and blocks them from binding to naturally produced androgens. With long term use, there is a gradual reduction in type 2 isozyme 5-alpha-reductase activity. It is this activity that converts testosterone to the more potent, hair follicle stimulating, Dihydrotestosterone (DHT)
A note of caution, there are various side effects in using these medications, such as diuretic symptoms, breast enlargement, increased libido (decreased in men), and foetus abnormalities.
The main types of oral medication are Spironolactone, Finasteride, Flutamide, Cyproterone Acetate, Ketoconazole and Gonadotrophin.
Oral meds work as a hair removal method by reducing the production of androgens (e.g. testosterone), binding to the cell's androgen receptors, and reducing the conversion of androgens to hair follicle stimulating chemicals (i.e. Dihydrotestosterone - DHT). They act to inhibit the growth of hair rather than to remove hairs per se.
Oral meds work as a hair removal method by reducing the production of androgens (e.g. testosterone
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