lidocaine powder with lidocaine crystal ball CAS 137-58-6

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USD $12.00 / Piece
Place Of Origin
china
Minimum Order
1
Packaging
by drum
Delivery
15 Days
Description Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).
Related Catalog
Signaling Pathways
Research Areas
References [1]. VAN DER Wal S, et al. Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice. Acta Anaesthesiol Scand. 2014 Oct 14.

[2]. Acevedo-Arcique CM, et al. Lidocaine, dexmedetomidine and their combination reduce isoflurane minimum alveolar concentration in dogs. PLoS One. 2014 Sep 18;9(9):e106620.

Chemical & Physical Properties

Boiling Point 350.8ºC at 760 mmHg
Melting Point 80-82°C
Molecular Formula C14H23ClN2O
Molecular Weight 270.798
Flash Point 166ºC
Exact Mass 270.149902
PSA 32.34000
LogP 3.45870
Storage condition Refrigerator
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CAS 137-58-6 lidocaine
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Procaine CAS 59-46-1 Lidocaine CAS137-58-6 Benzocaine HCl CAS23239-88-5 Tetracaine HCl CAS136-47-0 CAS No. 59-46-1 Other Names Procine Molecular Formula C13h20n2o2 EINECS No 200-426-9 Place of Origin hebei Province Purity 99% Form Powder Uses :Local anesthetics. Its toxicity is ...

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