Description | Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes). |
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Research Areas
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References |
[1]. VAN DER Wal S, et al. Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice. Acta Anaesthesiol Scand. 2014 Oct 14.
[2]. Acevedo-Arcique CM, et al. Lidocaine, dexmedetomidine and their combination reduce isoflurane minimum alveolar concentration in dogs. PLoS One. 2014 Sep 18;9(9):e106620. |
Boiling Point | 350.8ºC at 760 mmHg |
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Melting Point | 80-82°C |
Molecular Formula | C14H23ClN2O |
Molecular Weight | 270.798 |
Flash Point | 166ºC |
Exact Mass | 270.149902 |
PSA | 32.34000 |
LogP | 3.45870 |
Storage condition | Refrigerator |
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LignocaineCAS No.137-58-6 Email:rli282191 atgmaildotcomsales athbhonsdotcom whatsapp/ skype/ telegram: 8617103182350 Wickr me:pmkoil [Name] Xylocaine [CAS] 137-58-6 [Synonyms] 4,4\'-DIMETHOXY DIPHENYL SULFOXIDE LIDOCAINE-D6 2-(Diethylamino)-2\',6\'-acetoxylidide ...
公用名 利多卡因 化学适应诊断号 137-58-6 分子量 234.337 密度 1.0±0.1 克/厘米3 沸点 372.7±52.0 °C,760 mmHg 时 分子式 C14H22N2O 熔点 66-69°C 化学品安全数据表 中文 闪点 179.2±30.7 °C 象征 GHS07 信号字 警告 ...
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