Product Name: GW0742
CAS:317318-84-6
FW:C21H17F4NO3S2
MW:471.4846
Appearance: White powder
Purity: 99.% min
Package: 10g/bag or as customers'request.
Test Method: HPLC
Benefit:The effects of a high-affinity PPAR-β/δ agonist, GW0742, in a mouse model of carrageenan (CAR)-induced pleurisy. Injection of CAR into the pleural cavity of mice elicited an acute
inflammatory response characterized by accumulation of fluid containing a large number of neutrophils (polymorphonuclear leukocytes) in the pleural cavity, infiltration of polymorphonuclear
leukocytes in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, TNF-α, and IL-1β. Furthermore, CAR induced lung apoptosis (Bax and Bcl-2 expression), and
nitrotyrosine formation was determined by immunohistochemical analysis of lung tissues. Administration of GW0742 (0.3 mg/kg, i.p. bolus) 30 min before and 30 min after a challenge with CAR caused a
reduction in all the parameters of inflammation measured. Thus, based on these findings, we propose that a PPAR-β/δ agonist such as GW0742 may be useful in the treatment of various inflammatory
diseases.
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