94-09-7 Benzocaine

Minimum Order: 1

Packaging: N/A

Delivery: 15 Days

Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type[1]. The inhibition of Ca2+ uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity[2].
In Vivo	A common Benzocaine-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing[3].

Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type[1]. The inhibition of Ca2+ uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity[2].

In Vivo

A common Benzocaine-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing[3].

Country:
Business Type:
Market:
Founded Year:
Address:
Contact:Aimee smith

*Your name:	Enter name here eg:Ralph zhang
*Your Email:	Enter email here
*To:	SHHANGHAI DUMI BIOTECNOLOGY CO.,LTD
*Subject:
*Message:
	Enter between 20 to 3,000 characters. English only. Characters : 0 / 3000
*Enter the secure code shown below	Reload Image

		We do inquire for you , please wait ...

riboflavin-5'-phosphate sodium salt dihydrateCAS6184-17-4

Calcium L-Threonate CAS70753-61-6

L-Threonic acid magnesium saltCAS778571-57-6

Aminolevulinic acidCAS106-60-5

L-HydroxyprolineCAS 51-35-4

CAS 94-09-7 Benzocaine

14030-76-3 Etazene 14176-50-2 Tiletamine hydrochloride 14680-51-4 Metonitazene 71368-80-4 Bromazolam 109555-87-5 3-(1-Naphthoyl)indole 119276-01-6 Protonitazene (hydrochloride) 2647-50-9 Flubromazepam 2894-61-3 Bromonordiazepam 28981-97-7 Alprazolam 2732926-24-6 N-desethyl ...

Hebei Fangpai New Material Technology

CAS 94-09-7 benzocaine

We have our own factory We can provide good products at reasonable prices. We can send it free of charge, but you have to pay the freight. People who need to study chemicals for medical and laboratory technical purposes look forward to your contact. ...

Hebei Fangpai

CAS:94-09-7

WhatsAPP/Skype:+8615373986773 Threema ID ：8SK4RPWN Email：fp@hbfangpai.com Telegram :+8615373986773 CAS：14680-51-4 CAS：2732926-24-6 CAS：71368-80-4 CAS：2894-61-3 CAS：2647-50-9 CAS：40054-73-7 CAS： 40054-69-1 CAS：28981-97-7 CAS：111982-50-4 2fdck ...

河北方派hebeifangpai

CAS:94-09-7

河北方派

Benzocaine

Place of Origin: China Product Name: Benzocaine Cas No.:94-09-7 Purity: >99.5% Appearance: white powder Packing: Aluminum Foil Bag or Plastic Bag Delivery & Shipping Terms: 1. We will ship the goods within 3 days after payment. 2. We will ship the goods by UPS, EMS, DHL, TNT or ...

Hebei Muhuang Technology

(p-(Ethoxycarbonyl)phenylaMine 94-09-7

Benzocaine CAS No. 94-09-7 Email:rli282191 at gmail dot com sales at hbhons dot com whatsapp/ skype/ telegram: 8617103182350 Wickr me: pmkoil [Name] Benzocaine [CAS] 94-09-7 [Synonyms] 4-AMINOBENZOIC ACID ETHYL ESTER AETHOFORM AKOS BBS-00003658 anesthesin auralgan otic ...

Hons (Hebei) New Material Technology Co. Ltd

CAS 94-09-7 Benzocaine

Hot Sell: apihp eu 2f 5cl.adb、adbb raw material 4fmd.mb- 5fmd.emb..2201 most popular product, good price contact me： Whatsapp:+86 19333016343 Email: sales04@dmbiotechnology.com Wickr:alicelinana ...

Safe Delivery 99% Purity Benzocaine Powder CAS 94-09-7 Price for Sale in EU Warehouse(shengzhikai2@shengzhikai.com ))

Model NO. 94-09-7 Colour White Product Name Benzocaine HCl / Benzocaine Base Keywords Benzocaine Other Name Benzocaine Powder CAS 94-09-7 MW 165.19 Density 1.17 Application Pharmaceutical Intermediates Similar Products Caine COA Avaliable MOQ 1kg Sample Avaliable Brand ...

Shengzhikai Biotech

Benzocaine Fu5b Lidocaine whatsapp;008613165546610

Related Products: Benzocaine CAS 94-09-7 Lidocaine CAS 137-58-6 Tetracaine CAS 94-24-6 Procaine CAS 59-46-1 Procaine Hcl CAS 51-05-8 Tetracaine Hcl CAS 136-47-0 win35428 rti-111 CBD EK BU EU ...

hebei jiangkai

Factory supply Benzocaine 94-09-7 guarantee delivery

Benzocaine CAS.94-09-7 Benzocaine hcl Benzocaine hydrochloride CAS.23239-88-5 james at curepharmas dot com skype: cotanjames whatsapp/LINET/Telegram/Signal:+8613802264524 wickr: steroid825 Gurantee 100% safe shipping to USA Europe Canada Mexico, free of customs clearance. We ...

curepharma