L-Epinephrine hydrochloride CAS 329-63-5 smooth muscle relaxation

Adrenaline hydrochloride is a vasoactive drug of anti shock, for the rescue of cardiac arrest and allergic shock, can also be used for other allergic diseases (such as asthma, urticaria) treatment. Combined with local anesthetics favorable local hemostasis and prolong the effect of medicine.

L-Epinephrine hydrochloride is the active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

Epinephrine Hydrochloride is the hydrochloride salt of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation

Applications:

As a first aid to restore cardiac function: commonly used in anaphylactic shock, drowning, infectious diseases, drug poisoning, surgical accidents and cardiac conduction block caused by weak or sudden cardiac arrest. Heartbeat completely stopped, can be used intracardiac injection, and with effective artificial respiration, cardiac massage and other measures.

For allergic diseases: subcutaneous or intramuscular injection can treat allergic diseases such as anaphylactic shock, urticaria, bronchial asthma, lobular inflammation, immune serum and vaccine-induced allergic reactions are also effective.

Compatibility with local anesthetics Application: Per 100ml local anesthetic by adding 0.1% epinephrine solution 0.5 ~ 1ml, to shrink the local blood vessels, delay the absorption of local anesthetic, anesthesia time can be extended to reduce the toxicity of anesthetic reactions.