Qingdao Cemo Technology Develop Co., Ltd Gold product.
3'-Chloropropiophenone Basic information
Product Name:3'-Chloropropiophenone
Synonyms:3-CHLOROPHENYL ETHYL KETONE;(3-CHLOROPHENYL)PROPAN-1-ONE;M-CHLOROPROPIOPHENONE;MCPP;1-(3-CHLOROPHENYL)-1-PROPANONE;3-CHLORO-1-PHENYL-PROPANONE;3-CHLOROPROPIOPHENONE M-CHLORO PROPIOPHENONE;3-Chloro-Propiophenone(M-ChloroProiophenone)
CAS:34841-35-5
MF:C9H9ClO
MW:168.62
EINECS:252-242-3
Product Categories:C9;Carbonyl Compounds;Aromatic Propiophenones (substituted);Aromatic Ketones (substituted);Aromatic Halides (substituted);Ketones
Mol File:34841-35-5.mol
3'-Chloropropiophenone Structure
3'-Chloropropiophenone Chemical Properties
Melting point45-47 °C(lit.)
Boiling point124 °C14 mm Hg(lit.)
density1.1115 (rough estimate)
refractive index1.5350 (estimate)
Fp>230 °F
storage temp.Sealed in dry,Room Temperature
solubilitySoluble in methanol.
formCrystalline Solid
colorWhite to light yellow
InChIKeyPQWGFUFROKIJBO-UHFFFAOYSA-N
CAS DataBase Reference34841-35-5(CAS DataBase Reference)
Safety Information
Hazard CodesXi
Risk Statements36/37/38
Safety Statements37/39-26-24/25
WGK Germany3
HS Code29147000
MSDS Information
ProviderLanguage
1-(3-Chlorophenyl)-1-propanoneEnglish
SigmaAldrichEnglish
ACROSEnglish
ALFAEnglish
3'-Chloropropiophenone Usage And Synthesis
DescriptionInfluence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.
Chemical PropertiesWHITE TO LIGHT YELLOW CRYSTALLINE SOLID
Uses3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.
Uses3'-Chloropropiophenone has been used in the preparation of 1-(3-chlorophenyl)-1-phenyl-1-propanol.
Application3′-Chloropropiophenone can be used as a reactant to synthesize:
(S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
(S)-Dapoxetine, a selective serotonin reuptake inhibitor.
Preparation4.86 g (0.2 mol) of magnesium turnings, 30 ml of dry diethyl ether and a grain of iodine are placed in a one liter three-necked round-bottomed flask equipped with a condenser, a calcium chloride drying tube, a pressure equalizing funnel and a magnetic stirrer; the flask is purged with nitrogen, and 21.8 g (0.2 mol) of ethyl bromide in 30 ml of dry diethyl ether are then added. The mixture is then heated under reflux for one hour and left to cool. At ambient temperature, 16.51 g (0.12 mol) of 3-chlorobenzonitrile in 70 ml of dry diethyl ether are then added. A copious precipitate forms. The mixture is stirred overnight at ambient temperture and then cooled in an ice bath and hydrolysed by slowly adding 50 ml of water and then about 100 ml of 6N hydrochloric acid until the pH is acid. The mixture is stirred for one and a half hours and then extracted with ethyl acetate. The organic extract is then washed twice with water, dried and concentrated on a rotary evaporator. This gives 26 g of an orange oil, which is concentrated in vacuo to give about 18.2 g of ochre crystals of 3'-chloropropiophenone melting at about 40° C.
Literature source US04690931
General Description
Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.
Qingdao Cemo Technology Develop Co., Ltd.
Guanlang Group
Davy Lee
Mobile/whatsapp/wechat:+8619930503208
E-mail:davy@crovellbio.com/
Add:Room 30b-E10, No. 15 Donghai West Road, Shinan District, Qingdao City, Shandong Province, Qingdao, Shandong, China
Whatsapp/Telegram/Skype/Facebook/Viber/Line: +86 17041116544 Email:ciarahonshappy@gmail.com; ciara@hbhons.com Wickr me: MiaZhao Company introduction 1. Company Introduce Hons (Hebei) New Material Technology Co., Ltd. is one of the leading pharmaceutical manufacturer in China, ...
联系我们 WhatsApp/WeChat/Skype/Telegram:+8617332980887 Email: corrine@hbwego.com Wickr me:corrine hu 热销 Cas 79099-07-3 粉末 N-tert-Butoxycarbonyl-4- piperidone cas 288573-56-8 1- tert-Butoxycarbonyl-4-[(4-fluorophenyl)amino]piperidine cas443998-65-0 ...
China Flavor Manufacturer Supply High Purity Food Grade Cas 98-86-2 Acetophenone seller from China Are you looking for Acetophenone ? We are the biggest Acetophenone Manufacturer supplier in China.We can provide high purity Acetophenone with best price and fast delivery.We also ...
Email:zoey@crovellbio.com Whatsapp:+8619930503285 Wickr me: zoey456 Hot selling chemical raw material3\'-Chloropropiophenone G Biotechnology Co.,Ltd, Now we produce3\'-Chloropropiophenone Own3\'-Chloropropiophenone Our3\'-Chloropropiophenone Please contact me ...
我厂目前生产高纯度99% 3\'-氯苯丙酮粉末,不仅纯度高,而且价格实惠。现在 我们发现最重要的用途是3-氯苯丙酮是合成盐酸安非他酮的关键中间体, ...
Email:zoey@crovellbio.com Whatsapp:+8619930503285 Wickr me: zoey456 Hot selling chemical raw material3\'-Chloropropiophenone G Biotechnology Co.,Ltd, Now we produce3\'-Chloropropiophenone Own3\'-Chloropropiophenone Our3\'-Chloropropiophenone Please contact me ...
Qingdao Cemo Technology Develop Co., Ltd Gold product. 3\'-Chloropropiophenone Basic information Product Name:3\'-Chloropropiophenone Synonyms:3-CHLOROPHENYL ETHYL ...
Qingdao Cemo Technology Develop Co., Ltd Gold product. 3\'-Chloropropiophenone Basic information Product Name:3\'-Chloropropiophenone Synonyms:3-CHLOROPHENYL ETHYL ...
Hebei Guanlang Biotechnology Co., Ltd. Davy Lee Mobile/whatsapp/wechat:+8619930503208 E-mail: davy@crovellbio.com Add: No. 108, Zhongshan West Road, Qiaoxi District, Shijiazhuang,Hebei, China (Mainland) Cesium chloride Basic information Description Crystal structure Uses ...